Passive immunity with multi‐serotype heat‐killed Shigellae in neonatal mice |
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| Authors: | Soumik Barman Hemanta Koley Dhrubajyoti Nag Sumio Shinoda Gopinath Balakrish Nair Yoshifumi Takeda |
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| Institution: | 1. National Institute of Cholera and Enteric Diseases,;2. Collaborative Research Center of Okayama University for Infectious Diseases in India, , Kolkata, 700010;3. Translational Health Science and Technology Institute, , Gurgaon, Haryana 122016, India |
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| Abstract: | The short‐ and long‐term passive protective efficacy of a mixture of heat‐killed cells of six serogroups/serotypes of Shigella strains (Shigella dysenteriae 1, S. flexneri 2a, S. flexneri 3a, S. flexneri 6, S. boydii 4, and S. sonnei) were studied in neonatal mice. Neonatal mice from immunized dams exhibited significant short‐ and long‐term passive protection against individual challenge by each of the six Shigella strains. High IgG and IgA titers against the lipopolysaccharide from each of the six Shigella strains were observed in sera from immunized dams. |
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| Keywords: | heat‐killed Shigellae multivalent Shigella immunogen passive immunity Shigella vaccine |
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