| 海南粗榧内生真菌抗肿瘤抗菌活性的筛选 |
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| 引用本文： | 戴文君,戴好富,陈 苹,吴 娇,梅文莉.海南粗榧内生真菌抗肿瘤抗菌活性的筛选[J].微生物学通报,2009,36(8):1217-1221. |
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| 作者姓名： | 戴文君 戴好富 陈 苹 吴 娇 梅文莉 |
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| 作者单位： | 中国热带农业科学院,热带生物技术研究所,农业部热带作物生物技术重点开放实验室,海南,海口,571101 |
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| 基金项目： | 国家自然科学基金(No. 30560018); 973计划前期研究专项(No. 2007CB116306) |
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| 摘 要： | 对72株海南粗榧(Cephalotaxus hainanensis Li)内生真菌进行了抗肿瘤和抗菌活性筛选。结果显示, 有9株内生真菌至少对一种指示瘤株具有细胞毒活性, 5株内生真菌对金黄色葡萄球菌有较强的抑菌活性, 1株内生真菌对辣椒疫霉有抑制作用。这表明海南粗榧内生真菌是寻找有价值的生物活性成分的潜在资源, 其生物活性成分值得进一步研究。
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| 关 键 词： | 海南粗榧 内生真菌 细胞毒活性 抗菌活性 |
Screening of Antitumor and Antimicrobial Activities of the Endophytic Fungi Isolated from Cephalotaxus hainanensis L |
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| DAI Wen-Jun,DAI Hao-Fu,CHEN Ping,WU Jiao and MEI Wen-Li.Screening of Antitumor and Antimicrobial Activities of the Endophytic Fungi Isolated from Cephalotaxus hainanensis L[J].Microbiology,2009,36(8):1217-1221. |
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| Authors: | DAI Wen-Jun DAI Hao-Fu CHEN Ping WU Jiao and MEI Wen-Li |
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| Institution: | Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China;Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China;Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China;Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China;Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China |
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| Abstract: | Seventy-two endophytic fungi isolated from Cephalotaxus hainanensis Li were screened for antitumor and antimicrobial activities. The results showed that 9 strains presented cytotoxic activities to at least one of the tested tumor cells, five strains exhibited strong antimicrobial activity against Staphylococcus aureus, one strain had inhibitory effect on Phytophthora parasitica. It was evidently that the endophytic fungi of C. hainanensis are potential resources to find valuable bioactive components. |
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| Keywords: | Cephalotaxus hainanensis Li Endophytic fungi Cytotoxic activity Antimicrobial activity |
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