| 冠状病毒S蛋白及其受体的结构和功能 |
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| 引用本文： | 沈媚,陈冰清,于瑞嵩,朱于敏,李震.冠状病毒S蛋白及其受体的结构和功能[J].微生物学通报,2017,44(10):2452-2462. |
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| 作者姓名： | 沈媚 陈冰清 于瑞嵩 朱于敏 李震 |
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| 作者单位： | 1. 上海海洋大学水产与生命学院 上海 201306;2. 上海市农业科学院畜牧兽医研究所 上海 201106,2. 上海市农业科学院畜牧兽医研究所 上海 201106;3. 上海市农业遗传育种重点实验室 上海 201106,2. 上海市农业科学院畜牧兽医研究所 上海 201106;3. 上海市农业遗传育种重点实验室 上海 201106,2. 上海市农业科学院畜牧兽医研究所 上海 201106;3. 上海市农业遗传育种重点实验室 上海 201106,2. 上海市农业科学院畜牧兽医研究所 上海 201106;3. 上海市农业遗传育种重点实验室 上海 201106 |
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| 基金项目： | 上海市科技兴农重点攻关项目(沪农科攻字(2015)第6-1-9号)；国家自然科学基金项目(No. 31402219，315725199)；国家重点研发计划项目(No. 2016YFD0500101) |
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| 摘 要： | 冠状病毒是有包膜的单股正链RNA病毒。作为人和动物的重要致病原,冠状病毒感染主要导致宿主呼吸系统、肝脏、胃肠道以及神经系统出现急性或慢性症状。2000年以来,传染性非典型肺炎和中东呼吸综合征的暴发,以及猪流行性腹泻病毒在全球猪群中的暴发流行,引起大家对动物冠状病毒的极大重视。S蛋白具有受体结合活性和膜融合活性,是冠状病毒感染细胞的关键蛋白;S蛋白在病毒的组织或宿主嗜性和毒力等方面发挥重要作用。本文重点对近年来冠状病毒S蛋白的结构、功能以及S蛋白与受体相互作用的研究进行综述,以期为冠状病毒的入侵机制和反向遗传学研究以及受体阻断药物的开发提供参考。
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| 关 键 词： | 冠状病毒，S蛋白，受体，结构，功能 |
Structure and function of coronaviral S proteins and their receptors |
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| SHEN Mei,CHEN Bing-Qing,YU Rui-Song,ZHU Yu-Min and LI Zhen.Structure and function of coronaviral S proteins and their receptors[J].Microbiology,2017,44(10):2452-2462. |
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| Authors: | SHEN Mei CHEN Bing-Qing YU Rui-Song ZHU Yu-Min and LI Zhen |
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| Institution: | 1. College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China;2. Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China,2. Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China;3. Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai 201106, China,2. Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China;3. Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai 201106, China,2. Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China;3. Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai 201106, China and 2. Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China;3. Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai 201106, China |
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| Abstract: | Coronaviruses are enveloped viruses carrying single stranded and positive RNA genome. The viruses are important human and animal pathogens, causing acute or chronic symptoms in respiratory, nerve, liver, gastrointestinal tract. From 2000, epidemics of SARS (Severe acute respiratory syndrome) and MERS (Middle East respiratory syndrome) in human population and worldwide epidemic of PEDV (Porcine epidemic diarrhea virus) in pig population have made coronaviruses the focus of scientific research. Coronavirus S protein is the key protein involved in receptor recognition and membrane fusion. The S protein plays an important role in virus tissue or host tropism and virulence. This article reviewed the recent studies on structure and function of coronaviral S protein, and the interaction between the S proteins and their receptors, aiming to provide more information for research on the viral invasion mechanism, reverse genetics as well as the development of receptor blocking drugs. |
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| Keywords: | Coronaviruses S protein Receptors Structure Function |
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