| 密度感应系统：对细菌致病力的自行调控 |
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| 引用本文： | 杨登辉,孔里程,孙建和,严亚贤.密度感应系统：对细菌致病力的自行调控[J].微生物学通报,2017,44(12):3007-3014. |
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| 作者姓名： | 杨登辉 孔里程 孙建和 严亚贤 |
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| 作者单位： | 上海交通大学农业与生物学院 上海市兽医生物技术重点实验室 上海 200240,上海交通大学农业与生物学院 上海市兽医生物技术重点实验室 上海 200240,上海交通大学农业与生物学院 上海市兽医生物技术重点实验室 上海 200240,上海交通大学农业与生物学院 上海市兽医生物技术重点实验室 上海 200240 |
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| 基金项目： | 国家自然科学基金项目(No. 31272580，31372500，31772744)；国家公益性行业(农业)科研专项项目(No. 201303041) |
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| 摘 要： | 细菌通过密度感应系统感受环境中的信号分子,进而调控菌群一系列生物学性状。研究发现密度感应系统能够调控细菌生物被膜形成、毒力基因表达及噬菌体感染等功能,其中基于密度感应系统调控细菌抵御噬菌体感染更是新发现,预期也将是未来数年的研究热点,其调控机制的阐明将为有效应用噬菌体开展耐药菌的防控展现广阔前景。本文将重点综述细菌密度感应系统对细菌致病相关功能的调控机制,旨在为病原菌的防控提供新思路。
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| 关 键 词： | 密度感应，调控，致病力，生物被膜，噬菌体 |
Quorum sensing: an auto regulator for bacterial pathogenicity |
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| YANG Deng-Hui,KONG Li-Cheng,SUN Jian-He and YAN Ya-Xian.Quorum sensing: an auto regulator for bacterial pathogenicity[J].Microbiology,2017,44(12):3007-3014. |
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| Authors: | YANG Deng-Hui KONG Li-Cheng SUN Jian-He and YAN Ya-Xian |
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| Institution: | Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China,Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China,Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China and Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China |
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| Abstract: | Bacteria could sense the signal molecules and regulate their physiological behavior via quorum sensing (QS). QS is involved in the regulation of biofilm formation, virulent genes expression as well as the phages infection. QS could control adaptive immunity through the regulation of CRISPR-Cas systems, which is the latest finding and presumed to be the highlight in the near future. To elucidate its regulating mechanisms and reveal broad prospect for bacterial therapy by phage, we reviewed QS regulating mechanisms on bacterial pathogenicity for the control of pathogenic bacteria. |
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| Keywords: | Quorum sensing regulation pathogenicity biofilm bacteriophage |
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