| 苏云金芽孢杆菌双组份信号转导系统的生物信息学分析 |
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| 引用本文： | 张清仪,王阶平,程钢,刘钟慧,范文瑾,何进.苏云金芽孢杆菌双组份信号转导系统的生物信息学分析[J].微生物学通报,2011,38(9):1385-1392. |
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| 作者姓名： | 张清仪 王阶平 程钢 刘钟慧 范文瑾 何进 |
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| 作者单位： | 1. 华中农业大学生命科学技术学院农业微生物学国家重点实验室 湖北武汉430070
2. 中南民族大学生命科学学院 湖北武汉430074 |
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| 基金项目： | 国家自然科学基金重点项目(No. 30930004) |
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| 摘 要： | 苏云金芽孢杆菌(Bacillus thuringiensis)能产生杀虫晶体蛋白等多种活性成分,是目前应用最广泛的微生物杀虫剂。本文采用生物信息学方法,系统分析了由本实验室完成全基因组测序的苏云金芽孢杆菌YBT-1520、CT-43和BMB171 3个菌株的双组分信号转导系统(Two-componentsignal transduction system,TCS)的分布、结构及功能,并初步构建了部分TCS的调控网络关系图。本研究旨在为深入研究苏云金芽孢杆菌的生长、代谢以及毒力因子的表达与调控,全面了解伴孢晶体的形成机制开辟新的研究方向。
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| 关 键 词： | 苏云金芽孢杆菌 双组分信号转导系统 调控网络 生物信息学分析 |
Bioinformatics analysis of two-component signal transduction systems of Bacillus thuringiensis |
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| ZHANG Qing-Yi,WANG Jie-Ping,CHENG Gang,LIU Zhong-Hui,FAN Wen-Jin and HE Jin.Bioinformatics analysis of two-component signal transduction systems of Bacillus thuringiensis[J].Microbiology,2011,38(9):1385-1392. |
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| Authors: | ZHANG Qing-Yi WANG Jie-Ping CHENG Gang LIU Zhong-Hui FAN Wen-Jin and HE Jin |
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| Institution: | 1. State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China;1. State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China;2. College of Life Science, South-Central University for Nationalities, Wuhan, Hubei 430074, China;1. State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China;1. State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China;1. State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China |
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| Abstract: | Bacillus thuringiensis (Bt) strains, which can produce insecticidal crystal proteins, were widely used as biological pesticides. In this paper, we comprehensively analyzed the distributions, structures and putative biological functions of two-component transduction systems (TCS) from the genomes of Bt strains YBT-1520, CT-43 and BMB171, which have been sequenced by our laboratory. And more importantly, we constructed a preliminary TCS regulatory networks. This study should open a novel research direction in Bt for the growth, metabolism, regulator of toxic gene expression, as well as the formation mechanism of parasporal crystals. |
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| Keywords: | Bacillus thuringiensis Two-component signal transduction systems Regulatory network Bioinformatics analysis |
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