鸭疫里默氏杆菌铁离子代谢机制研究进展

铁离子是大多数细菌生存所必需的一种营养物质，但过多的铁离子会通过芬顿反应产生的活性氧对细菌造成损伤。因此，细菌通过摄取、调控、螯合、外排等机制维持体内铁离子的稳态。鸭疫里默氏杆菌(Riemerella anatipestifer)是一种最新被归类于威克斯菌科里氏杆菌属的革兰氏阴性菌。该菌主要感染禽类，参与该菌的铁离子代谢基因具有特别之处。本文对鸭疫里默氏杆菌铁离子代谢机制研究进展进行了系统总结和阐述，包括该菌的TonB系统、TonB依赖性受体、Fur蛋白及Dps蛋白等在铁离子转运、调控、螯合中的功能，以及以上蛋白在鸭疫里默氏杆菌致病中的作用，以期更全面地理解鸭疫里默氏杆菌铁代谢机制，并为进一步深入研究该菌铁离子代谢提供理论依据和参考。

Research advances on the iron metabolism of Riemerella anatipestifer

Iron is an essential nutrient for the survival of most bacteria. However, excessive iron will cause damage to bacteria through the reactive oxygen species produced by Fenton reaction. Bacteria usually maintain the iron homeostasis via a variety of mechanisms including uptake, regulation, chelation, and efflux. Riemerella anatipestifer is a Gram-negative bacterium newly categorized into Riemerella, a genus of Weeksellaceae. Because R. anatipestifer mainly infects poultry, the genes involved in the iron metabolism of this bacterium have unique characteristics. In this review, the research progress of iron metabolism in this bacterium was systematically summarized and elaborated. It includes that the roles of TonB system, TonB-dependent receptors, and Fur and Dps proteins in the import, regulation, and chelation of iron, as well as in the pathogenesis of R. anatipestifer. It will provide valuable information for fully understanding the mechanisms of iron homeostasis and for further research of the iron metabolism of R. anatipestifer.