| 食气梭菌的研究进展 |
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| 引用本文： | 贾德臣,姜卫红,顾阳.食气梭菌的研究进展[J].微生物学通报,2019,46(2):374-387. |
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| 作者姓名： | 贾德臣 姜卫红 顾阳 |
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| 作者单位： | 1 中国科学院分子植物科学卓越创新中心 植物生理生态研究所 合成生物学重点实验室 上海 200032;2 中国科学院大学 北京 100039,1 中国科学院分子植物科学卓越创新中心 植物生理生态研究所 合成生物学重点实验室 上海 200032,1 中国科学院分子植物科学卓越创新中心 植物生理生态研究所 合成生物学重点实验室 上海 200032 |
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| 基金项目： | 上海市科学技术委员会科研计划(17JC1404800)；国家自然科学基金(31630003)；中国科学院青年创新促进会优秀会员人才专项(2012213)；吐露港生物科技未来发展基金(2018-07(GY) |
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| 摘 要： | 食气梭菌是一类主要的化能自养微生物,可利用二氧化碳(CO_2)和一氧化碳(CO)合成多种化学品和燃料,具有良好的工业应用前景。天然的食气梭菌吸收、固定和转化一碳气体速率较慢,能量代谢效率低且高值产物种类少。近年来,随着组学、分子遗传学工具以及生化分析技术的快速发展,食气梭菌的生理代谢特点及其相关分子机制、代谢工程设计、改造和发酵工艺等方面都得到广泛而深入的研究。本文针对近年来食气梭菌的研究进展进行了梳理和总结,以期能为这类重要工业微生物的基础和应用研究,以及一碳气体的生物转化利用提供参考。
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| 关 键 词： | 食气梭菌，一碳气体，分子工具，遗传改造，发酵工艺 |
Research progresses in gas-fermenting clostridia |
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| JIA De-Chen,JIANG Wei-Hong and GU Yang.Research progresses in gas-fermenting clostridia[J].Microbiology,2019,46(2):374-387. |
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| Authors: | JIA De-Chen JIANG Wei-Hong and GU Yang |
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| Institution: | 1 Key Laboratory of Synthetic Biology, Centre for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China;2 University of Chinese Academy of Sciences, Beijing 100039, China,1 Key Laboratory of Synthetic Biology, Centre for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China and 1 Key Laboratory of Synthetic Biology, Centre for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China |
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| Abstract: | Gas-fermenting clostridia is a major class of chemoautotrophs that uses CO2 and CO to synthesize a variety of chemicals and fuels, thereby exhibiting good industrial application prospects. Wild-type gas-fermenting Clostridium species are inefficient in gas uptake, fixation and conversion and energy metabolism, and moreover, incompetent to produce high value products. In recent years, with the rapid development of omics, molecular genetic tools and biochemical techniques in gas-fermenting clostridia of which the physiology and metabolism as well as the underlying molecular mechanisms, metabolic design and engineering, and fermentation technologies have been widely studied. Here, we review the latest research progresses in gas-fermenting clostridia to provide information on these industrial microorganisms and bio-utilization of one-carbon gases. |
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| Keywords: | Gas-fermenting clostridia one-carbon gases molecular tools genetic modification fermentation process |
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