| 口蹄疫病毒反向遗传学研究进展 |
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| 引用本文： | 白兴文,李平花,刘在新,刘湘涛,谢庆阁.口蹄疫病毒反向遗传学研究进展[J].微生物学通报,2009,36(1):0106-0112. |
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| 作者姓名： | 白兴文 李平花 刘在新 刘湘涛 谢庆阁 |
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| 作者单位： | 中国农业科学院兰州兽医研究所,家畜疫病病原生物学国家重点实验室,国家口蹄疫参考实验室,农业部畜禽病毒学重点开放实验室,甘肃,兰州,730046 |
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| 基金项目： | 国家“973项目”(No. 2005CB523201); “十一五”国家科技支撑计划项目(No. 2006BAD06A03) |
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| 摘 要： | 反向遗传学操作技术在口蹄疫病毒(FMDV)病原学基础研究领域的应用, 使得人们能够在基因组整体水平上研究病毒基因的功能。得益于反向遗传学系统的不断完善和发展, 目前人们对FMDV分子病原学也有了更加深入的认识和理解。本文结合实验室在FMDV反向遗传学方向上所开展的探索性研究工作, 综述了国内外利用反向遗传学操作技术在研究FMDV分子致病机制、病毒毒力与变异的关系、病毒复制的影响因素、新型FMD基因疫苗的研制等领域所取得的进展, 展望FMDV反向遗传学研究新动向。
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| 关 键 词： | 口蹄疫病毒 反向遗传学 感染性分子克隆 |
Recent Advances on Reverse Genetics of Foot-and-mouth Disease Virus |
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| BAI Xing-Wen,LI Ping-Hu,LIU Zai-Xin,LIU Xiang-Tao and XIE Qing-Ge.Recent Advances on Reverse Genetics of Foot-and-mouth Disease Virus[J].Microbiology,2009,36(1):0106-0112. |
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| Authors: | BAI Xing-Wen LI Ping-Hu LIU Zai-Xin LIU Xiang-Tao and XIE Qing-Ge |
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| Institution: | Lanzhou Veterinary Research Institute of Chinese Academy of Agricultural Sciences, State Key Laboratory of Veterinary Etiological biology, National Foot-and-Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture,;Lanzhou Veterinary Research Institute of Chinese Academy of Agricultural Sciences, State Key Laboratory of Veterinary Etiological biology, National Foot-and-Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture,;Lanzhou Veterinary Research Institute of Chinese Academy of Agricultural Sciences, State Key Laboratory of Veterinary Etiological biology, National Foot-and-Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture,;Lanzhou Veterinary Research Institute of Chinese Academy of Agricultural Sciences, State Key Laboratory of Veterinary Etiological biology, National Foot-and-Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture,;Lanzhou Veterinary Research Institute of Chinese Academy of Agricultural Sciences, State Key Laboratory of Veterinary Etiological biology, National Foot-and-Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, |
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| Abstract: | Usage of reverse genetic techniques in the research area of the fundamental etiology of foot-and-mouth disease virus (FMDV), has resolved the issue about the function of viral gene of FMDV on genomic integer level. At present, a further recognition and apprehension for the molecular etiology of FMDV based on the development in reverse genetics was made. Combined with the research work in our labs, we reviewed international advances about the molecular pathogenic mechanism, the relationship between virulence and variation in the genomes, influencing factors for the viral replication, and the development of new-type gene vaccine of FMD in this article, and propose the potential research aspects in reverse genetics of FMDV in the future. |
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| Keywords: | Foot-and-mouth disease virus Reverse genetics Infectious molecular clone |
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