生物被膜分散方式的研究进展

临床上生物被膜与感染的慢性迁延不愈密切相关，而生物被膜菌的分散又会造成感染的反复急性发作，给临床感染的有效控制带来很大困难。生物被膜菌的分散过程受到了遗传和环境等多因素的调控，主要是通过蜂式分散、块式分散和毯式分散3种形式来实现的。深入进行生物被膜基础研究对改变目前临床感染治疗的窘境有重大意义。

Advance in Biofilm Dispersal Strategies

Bacterial biofilm is responsible for a wide variety of nosocomial infections.Many chronic infectious diseases are closely correlated with biofilm formation in the clinic.As the biofilm growth,bacterial clusters detachment and dispersal from mature mixed-species biofilms will result in repeated acute infections.Here reviews three distinct biofilm dispersal strategies: swarming dispersal,clumping dispersal and surface dispersal.Many factors,such as heredity and increased fluid shear in the environment,contribute to this complex and dynamic process.Fundamental investigation upon biofilm will benefit clinical therapy of biofilm-associated infections.