| 基因工程菌生产抗菌肽的研究进展 |
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| 引用本文： | 黄佳明,姜宁,张爱忠.基因工程菌生产抗菌肽的研究进展[J].微生物学通报,2019,46(3):654-659. |
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| 作者姓名： | 黄佳明 姜宁 张爱忠 |
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| 作者单位： | 黑龙江八一农垦大学动物科技学院 黑龙江 大庆 163319,黑龙江八一农垦大学动物科技学院 黑龙江 大庆 163319,黑龙江八一农垦大学动物科技学院 黑龙江 大庆 163319 |
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| 基金项目： | 国家自然科学基金(31472120) |
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| 摘 要： | 目前,利用基因工程菌生产抗菌肽,提供有效和稳定的方法是抗菌肽生产的热点之一。了解抗菌肽工程菌表达系统、生产量尤为重要,为此本文阐述了抗菌肽的生产方式,介绍了基因工程菌表达系统的种类、组成及特点,分析了基因工程菌生产抗菌肽的主要困难因素,并对近些年利用基因工程菌生产抗菌肽的进展进行了综述。
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| 关 键 词： | 抗菌肽，表达系统，基因工程菌 |
Progress in engineering bacteria producing antibacterial peptides |
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| HUANG Jia-Ming,JIANG Ning and ZHANG Ai-zhong.Progress in engineering bacteria producing antibacterial peptides[J].Microbiology,2019,46(3):654-659. |
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| Authors: | HUANG Jia-Ming JIANG Ning and ZHANG Ai-zhong |
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| Institution: | College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, China,College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, China and College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, China |
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| Abstract: | Recently, it is the one of the hot topic for antimicrobial peptides (AMPs) to be produced using recombinant expression system with efficiency and stable protocols. It is particularly crucial for us to know different expression systems we use and their production. For this purpose, we narrate methods to produce AMPs, species, elements and properties of different expression systems, mainly there is an analysis for some difficult factors to construct engineered bacteria. And, we also reviewed the progress of producing antibacterial peptides using engineered bacteria in recent years. |
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| Keywords: | Antibacterial peptide Expression system Genetically engineered bacteria |
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