| 氨基糖苷类抗生素JI-20A发酵过程的磷酸盐控制 |
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| 引用本文： | 陈剑锋,邵敬伟,张元兴,陈浩,郭养浩.氨基糖苷类抗生素JI-20A发酵过程的磷酸盐控制[J].微生物学通报,2007,34(5):0852-0855. |
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| 作者姓名： | 陈剑锋 邵敬伟 张元兴 陈浩 郭养浩 |
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| 作者单位： | 1. 福州大学药物生物技术与工程研究所,福州,350002
2. 华东理工大学生物反应器工程国家重点实验室,上海,200237 |
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| 基金项目： | 福建省科技三项费资助项目;福建省自然科学基金 |
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| 摘 要： | 磷酸盐初始浓度6.1mmol/L~9.6mmol/L有助于菌体的生长,但抑制氨基糖苷类抗生素JI-20A的合成。在产物合成期磷酸盐浓度控制在1.1mmol/L以下可提高碱性磷酸酯酶活力,降低丙酮酸浓度,促进氨基糖苷类抗生素JI-20A合成。
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| 关 键 词： | 抗生素JI-20A 磷酸盐 发酵 碱性磷酸酯酶 丙酮酸 |
| 文章编号： | 0253-2654（2007）05-0852-04 |
| 修稿时间： | 2006-09-20 |
Control of Phosphate Concentration on Aminoglycoside Antibiotic JI-20A Fermentation |
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| CHEN Jian-Feng,SHAO Jing-Wei,ZHANG Yuan-Xing,CHEN Hao and GUO Yang-Hao.Control of Phosphate Concentration on Aminoglycoside Antibiotic JI-20A Fermentation[J].Microbiology,2007,34(5):0852-0855. |
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| Authors: | CHEN Jian-Feng SHAO Jing-Wei ZHANG Yuan-Xing CHEN Hao and GUO Yang-Hao |
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| Institution: | Institute of Pharmaceutical Biotechnology and Engineering,Fuzhou University,Fuzhou 350002;Institute of Pharmaceutical Biotechnology and Engineering,Fuzhou University,Fuzhou 350002;State Key Laboratory of Bioreactor Engineering,East China University of Technology, Shanghai 200237;Institute of Pharmaceutical Biotechnology and Engineering,Fuzhou University,Fuzhou 350002;Institute of Pharmaceutical Biotechnology and Engineering,Fuzhou University,Fuzhou 350002 |
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| Abstract: | It was found that the phosphate concentration effected significantly on the cell growth and the production of aminoglycoside antibiotic JI- 20A. Although initial phosphate concentration of 6. 1mmol/L - 9.6 mmol/L was beneficial for the cell growth, the production of aminoglycoside antibiotic JI-20A was inhibited. When the phosphate concentration was controlled below 1.1 mmol/L in the biosynthesis phase of aminoglycoside antibiotic JI-20A, high alkaline phosphatase activity and low pyruvic acid concentration were resulted in, and the production of arninoglycoside antibiotic JI-20A was enhanced. |
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| Keywords: | Antibiotic JI-20A Phosphate Fermentation Alkaline phosphatase Pyruvic acid |
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