合成微生物体系研究进展

合成微生物体系作为自下而上构建的人工合成微生物群落,相比于自然微生物群落具有复杂度低及可控性、可操作性强等特点。其作为新兴的生物技术,综合借鉴了合成生物学、系统生物学、生物进化等知识,通过合理的设计、规划与调控,成为研究微生物生态学理论的实验平台,以及验证已知理论的微生物系统。本文首先简单介绍了合成微生物体系的概念及其由来,阐述了其基本构建原则,随后介绍了其生态学理论基础,并总结概括了近年来的实际应用,最后提出合成微生物体系的发展前景,包括需要设计构建更为复杂的人工合成微生物群落,以及优化生态模型。

Research progress in synthetic microbial systems

As a bottom-up constructed microbial community, the synthetic microbial system has the characteristics of low complexity, controllability and operability compared with natural microbial communities. It is an emerging biotechnology and draws on synthetic biology, systems biology, biological evolution and other knowledge. Furthermore, by rational designing, planning and regulating, it becomes an experimental platform for studying microbial ecology theory, and a microbial system for validating known theories. In this paper, we first briefly introduce the concept of synthetic microbial system and its origin, expound its basic construction principles. We then introduce its ecological theoretical basis, and summarize its applications in recent years. Finally, we present our outlook on the development of synthetic microbial system, including the need to design and construct more complex synthetic microbial communities, and to optimize ecological models.