炎症性肠病与艰难梭菌感染相关性研究的文献计量学和可视化分析

【背景】近年来，炎症性肠病患者中艰难梭菌（Clostridium difficile）感染率逐年上升，受到国内外学者广泛关注。我国在该领域的研究起步较晚，但患者数量众多，学习国际上对于炎症性肠病合并艰难梭菌感染的研究，对推动我国在该领域的深入发展具有重要意义。【目的】通过文献计量和可视化分析帮助研究者把握炎症性肠病与艰难梭菌感染相关性研究中的研究主题、方向、热点与前沿。【方法】同时检索Web of Science （WOS）中Science Citation Index Expanded （SCI-E）和CNKI中收录的关于炎症性肠病和艰难梭菌的相关文献，应用CiteSpace 6.2.2r软件进行国家/地区、机构、作者、关键词共现及被引文献、期刊共被引分析，同时进行可视化分析。【结果】经过数据检索和查重，最终可供分析的文献为WOS数据库1 030篇、CNKI数据库80篇。全球范围内，发文最多的国家是美国，主要研究机构有Harvard University、University of California System和Mayo Clinic等，高产作者有Khanna S、Shen B和Ananthakrishnan AN等，高频关键词包括Inflammatory bowel disease、Ulcerative colitis、Clostridium difficile、Clostridium difficile infection和Crohn’s disease等，聚类方向有#0 Diarrhea、#1 Ulcerative colitis、#2 Probiotics、#3 Pouchitis、#4 Gut microbiota、#5 Fecal microbiota transplantation、#6 Depression、#7 Entamoeba histolytica、#8 Pseudomembranous colitis、#9 Clostridium difficile和#10 Clindamycin。国内主要研究机构有南方医科大学和河北医科大学，高产作者有王浦、王斯淇等，高频关键词包括粪菌移植、艰难梭菌、肠道菌群、危险因素和克罗恩病等，聚类方向有#0艰难梭菌、#1益生菌、#2危险因素、#3腹泻和#4粪菌移植。【结论】利用CiteSpace软件对炎症性肠病和艰难梭菌感染相关性研究进行计量及可视化分析可知，该方向仍得到全球各医疗机构及研究者的关注，腹泻及粪菌移植这两个关键词分别代表了WOS数据库和CNKI数据库关于炎症性肠病合并艰难梭菌感染研究的热点。

Bibliometric and visual analysis on the association between inflammatory bowel disease and Clostridium difficile infection

Background] The recent years have witnessed the increasing incidence of Clostridium difficile infection (CDI) in patients with inflammatory bowel disease (IBD), which has attracted widespread attention from scholars. China started the research late in this field, while there were a large number of patients. Learning from international research on IBD combined with CDI is of great significance for improving China''s research in this field. Objective] To help researchers grasp the research topics, directions, hotspots, and frontiers in the correlation between IBD and CDI by bibliometric and visual analysis. Methods] The articles about CDI and IBD were searched against the Science Citation Index-Expanded (SCI-E) in the Web of Science (WOS) and CNKI. CiteSpace 6.2.2r was employed to analyze the authors, research institutions, countries, and keyword co-occurrence, citations, and journal co-citation, and the results were visualized. Results] After data retrieval and duplicate checking, 1 030 articles published by WOS and 80 articles by CNKI were included for analysis. On a global scale, the United States was the country with the most publications. The major research institutions included Harvard University, University of California System, and Mayo Clinic. The prolific authors included Khanna S, Shen B, and Ananthakrishnan AN. High-frequency keywords included Inflammatory bowel disease, Ulcerative colitis, Clostridium difficile, Clostridium difficile infection, and Crohn''s disease. The articles were clustered into the categories of Diarrhea, Ulcerative colitis, Probiotics, Pouchitis, Gut microbiota, Fecal microbiota transplantation, Depression, Entamoeba histolytica, Pseudomembranous colitis, Clostridium difficile, and Clindamycin. In China, the major research institutions included Southern Medical University and Hebei Medical University, and the prolific authors included WANG Pu and WANG Siqi. The high-frequency keywords included Fecal bacteria transplantation, Clostridium difficile, Gut microbiota, Risk factors, and Crohn''s disease. The articles in Chinese were clustered into the categories of Clostridium difficile, Probiotics, Risk factors, Diarrhea, and Fecal bacteria transplantation. Conclusion] The CiteSpace-based visual analysis of the correlation between CDI and IBD shows that this research direction still receives the attention from medical institutions and researchers worldwide. The keywords of Diarrhea and Fecal microbiota transplantation represent the research hotspots in the WOS and CNKI, respectively.