乳酸菌合成叶酸的研究进展

叶酸普遍存在于各类食物中，但由于叶酸的不稳定性以及饮食习惯的差异性，各国叶酸缺乏现象普遍存在。叶酸是参与核酸合成及细胞分裂分化的重要物质，叶酸缺乏引起机体功能的混乱，由此引发癌症等一系列的疾病。大部分乳酸菌是叶酸缺陷型菌株，但越来越多的研究表明其很多种类都具有叶酸合成能力。本文主要概述产叶酸乳酸菌的分类，乳酸菌生物合成叶酸的机制，以及利用乳酸菌进行的叶酸基因工程研究进展。

Research progress of the folate synthesized by lactic acid bacteria

Folate are presented in all kinds of foods, but folate deficiency in human body still exist in every country due to the difference of dietary habit and unstability of folate. Folate are the important material that participate in synthesis of nucleic acid and the cell division and differentiation. Folate deficiency lead to the disorders of body functions, thus lead to a serise disease such as cancer. Even though most lactic acid bacteria (LAB) are folate-defective strains, more and more studies indicated that a lot of strains among LAB have the capability to synthesize folate. This review summarized the progress on species of LAB with the capacity of synthesizing folate, their folate synthesis mechanism, and folate gene engineering carried by LAB.