| 群体感应(QS)在牙菌斑形成中的研究进展 |
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| 引用本文： | 高启禹,张文博,赵阳,徐光翠.群体感应(QS)在牙菌斑形成中的研究进展[J].微生物学通报,2015,42(7):1400-1408. |
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| 作者姓名： | 高启禹 张文博 赵阳 徐光翠 |
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| 作者单位： | 1. 河南新乡医学院生命科学技术学院 河南省遗传性疾病与分子靶向药物重点实验室培育基地河南 新乡 453003；2. 兰州大学 生命科学学院 甘肃 兰州 730000,1. 河南新乡医学院生命科学技术学院 河南省遗传性疾病与分子靶向药物重点实验室培育基地河南 新乡 453003,2. 兰州大学 生命科学学院 甘肃 兰州 730000,3. 河南新乡医学院 公共卫生学院 河南 新乡 453003 |
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| 基金项目： | 国家自然科学基金项目(No. 81370916)；新乡医学院培育基金项目(No. 2014QN132) |
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| 摘 要： | 形成牙菌斑的生物膜中存在大量微生物，各种微生物通过高丝氨酸内酯(AHL)或寡肽等不同的信号分子产生群体感应(QS)，形成的群体感应使各种微生物建立了区系平衡，对龋齿及牙周炎等口腔疾病的治疗产生严重影响。因组成生物膜的各种微生物对抗生素的敏感性和耐受性有显著差异，因此在治疗中增加了对宿主免疫的相应要求。为进一步探讨QS系统在牙菌斑形成中的作用特点，本文就牙菌斑的形成与抗药机制、群体感应系统及其信号分子、群体感应系统的抑制因子和研究展望进行综述。
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| 关 键 词： | 群体感应，牙菌斑，生物膜，信号分子，抑制剂 |
Recent advances in the study on the form of dental plaque with quorum sensing |
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| GAO Qi-Yu,ZHANG Wen-Bo,ZHAO Yang and XU Guang-Cui.Recent advances in the study on the form of dental plaque with quorum sensing[J].Microbiology,2015,42(7):1400-1408. |
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| Authors: | GAO Qi-Yu ZHANG Wen-Bo ZHAO Yang and XU Guang-Cui |
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| Institution: | 1. College of Life Science and Technology, Xinxiang Medical University, Henan Key Laboratory of Hereditary Disease and Molecular Target Drug Therapy (Cultivating Base), Xinxiang, Henan 453003, China; 2. School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China,1. College of Life Science and Technology, Xinxiang Medical University, Henan Key Laboratory of Hereditary Disease and Molecular Target Drug Therapy (Cultivating Base), Xinxiang, Henan 453003, China,2. School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China and 3. College of Public Health, Xinxiang Medical University, Xinxiang, Henan 453003, China |
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| Abstract: | Quorum sensing (QS), mediated by N-acyl homoserine lactones (AHL) and oligopeptides among various microbes in the dental plaque biofilm, maintains flora balance and severely affects dental caries, paradentitis and other oral diseases therapy. Currently, antibiotics are generally applied in treating these diseases. However, plaque microorganisms have significantly different sensitivity and tolerance to antibiotics. To circumvent the above disadvantages, host immune responses have to be considered in the dental therapy additionally, and to clarify plaque biofilm generation and the mechanisms of resistance, classification of signaling molecules and the quorum sensing formation related signal transduction system, inhibitors for plaque microbes and the perspectives were systematically summarized in this review. |
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| Keywords: | Quorum sensing Dental plaque Biofilm Signal molecule Inhabitor |
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