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γ-聚谷氨酸的微生物合成、相关基因及应用展望
引用本文:曹名锋,金映虹,解慧,王淑芳,宋存江.γ-聚谷氨酸的微生物合成、相关基因及应用展望[J].微生物学通报,2011,38(3):388-395.
作者姓名:曹名锋  金映虹  解慧  王淑芳  宋存江
作者单位:1. 南开大学生命科学学院微生物系分子微生物学与技术教育部重点实验室,天津,300071
2. 南开大学生命科学学院微生物系分子微生物学与技术教育部重点实验室,天津,300071;南开大学生命科学学院生物活性材料教育部重点实验室,天津,300071
3. 南开大学生命科学学院生物活性材料教育部重点实验室,天津,300071
基金项目:国家自然科学基金项目(No. 31070039, 51073081); 天津市科技支撑重点项目(No. 09ZCKFSH00800)
摘    要:γ-聚谷氨酸是一种具有极强水溶性、生物相容性、可完全降解性的环境友好型新材料。介绍γ-聚谷氨酸的基本性质、微生物合成及其影响因素,综述其合成相关基因、合成酶复合体的研究进展及在水凝胶和药物载体方面的应用前景。

关 键 词:γ-聚谷氨酸  生物合成  合成酶基因  应用前景
收稿时间:2010/7/14 0:00:00
修稿时间:2010/11/19 0:00:00

Biosynthesis of poly(γ-glutamic acid),its related genes and application prospects
CAO Ming-Feng,JIN Ying-Hong,XIE Hui,WANG Shu-Fang and SONG Cun-Jiang.Biosynthesis of poly(γ-glutamic acid),its related genes and application prospects[J].Microbiology,2011,38(3):388-395.
Authors:CAO Ming-Feng  JIN Ying-Hong  XIE Hui  WANG Shu-Fang and SONG Cun-Jiang
Institution:Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Department of Microbiology, Nankai University, Tianjin 300071, China;Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Department of Microbiology, Nankai University, Tianjin 300071, China; Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China;Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Department of Microbiology, Nankai University, Tianjin 300071, China;Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China;Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Department of Microbiology, Nankai University, Tianjin 300071, China; Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China
Abstract:Poly(γ-glutamic acid) is a promising environmental friendly material with outstanding water solubility,biocompatibility and degradability.This review introduces the basal properties of γ-PGA,microbial production of γ-PGA,and the key factors affecting the yield of γ-PGA.Furthermore,the γ-PGA biosynthesis genes,γ-PGA synthetase complex,as well as the application prospects of γ-PGA in hydrogel and drug delivery,are also discussed.
Keywords:Poly(γ-glutamic acid)  Biosynthesis  Synthetase genes  Application prospects
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