| 电子圆二色谱技术在微生物次级代谢产物结构研究中的应用研究进展 |
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| 引用本文： | 陈宁,武艺,刘冰,许颖,季宇彬.电子圆二色谱技术在微生物次级代谢产物结构研究中的应用研究进展[J].微生物学通报,2020,47(11):3699-3708. |
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| 作者姓名： | 陈宁 武艺 刘冰 许颖 季宇彬 |
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| 作者单位： | 1 哈尔滨商业大学药物工程技术研究中心 黑龙江 哈尔滨 150076;2 国家教育部抗肿瘤天然药物工程研究中心 黑龙江 哈尔滨 150076 |
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| 基金项目： | 黑龙江省自然科学基金(H2017001)；黑龙江省博士后基金(LBH-Z16095)；黑龙江省高等学校基本科研业务费科研项目(17XN010)；哈尔滨商业大学在站博士后支撑计划(2017BSH001，2017BSH003) |
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| 摘 要： | 微生物次级代谢产物的化学结构十分复杂，对其绝对构型的确定十分困难。近年来，电子圆二色谱(electronic circular dichroism，ECD)由于其用量少、精度高等优点，在测定绝对构型方面的应用越来越多，已经成为研究微生物次级代谢产物结构的重要方法。本文就电子圆二色谱在微生物次级代谢产物结构研究中的应用进行综述，以期为今后的研究奠定基础。
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| 关 键 词： | 微生物次级代谢产物，绝对构型，电子圆二色谱 |
Progress in the application of electronic circular dichroism technology in the structural study of microbial secondary metabolites |
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| CHEN Ning,WU Yi,LIU Bing,XU Ying,JI Yu-Bin.Progress in the application of electronic circular dichroism technology in the structural study of microbial secondary metabolites[J].Microbiology,2020,47(11):3699-3708. |
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| Authors: | CHEN Ning WU Yi LIU Bing XU Ying JI Yu-Bin |
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| Institution: | 1 Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin, Heilongjiang 150076, China;2 National Center for Anticancer Natural Medicine Engineering, Harbin, Heilongjiang 150076, China |
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| Abstract: | The chemistry construction of microbial secondary metabolites is complex, and the determination of their absolute configuration is very difficult. In recent years, electronic circular dichroism (ECD) has been used more and more in the determination of absolute configuration due to its advantages of low dosage and high accuracy, and it has become an important method to study the structure of microbial secondary metabolites. In this paper, the application of ECD in the structure of microbial secondary metabolites was reviewed, which laid a foundation for future research. |
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| Keywords: | Microbial secondary metabolites Absolute configuration Electronic circular dichroism |
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