| 细菌纳米磁小体有望作为靶向药物载体 |
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| 引用本文： | 孙建波,姜伟,李颖,张阳德,李季伦.细菌纳米磁小体有望作为靶向药物载体[J].微生物学通报,2007,34(1):0165-0168. |
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| 作者姓名： | 孙建波 姜伟 李颖 张阳德 李季伦 |
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| 作者单位： | 1. 中国农业大学生物学院农业部农业微生物资源与应用重点开放实验室,北京,100094
2. 中南大学湘雅医院卫生部纳米生物技术重点实验室,长沙,410008 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 趋磁细菌细胞内合成的纳米磁小体具有颗粒均匀,晶型稳定的特点,每个磁小体有脂膜包被。提纯的磁小体毒性低,生物相容性好,可作为多种药物和大分子化合物的载体而应用于定向治疗肿瘤。本文介绍了细菌磁小体的结构特点,提出了采用细菌磁小体连接抗癌药物的策略,讨论了建立磁小体载药体系靶向治疗癌症的可能性。
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| 关 键 词： | 趋磁细菌 磁小体 纳米载体 |
| 文章编号： | 0253-2654（2007）01-0165-04 |
| 修稿时间： | 2006-04-10 |
The Magnetosomes of Magnetotactic Bacteria May be Used as Drug-carriers for Targeted Therapy |
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| SUN Jian-Bo,JIANG Wei,LI Ying,ZHANG Yang-De and LI Ji-Lun.The Magnetosomes of Magnetotactic Bacteria May be Used as Drug-carriers for Targeted Therapy[J].Microbiology,2007,34(1):0165-0168. |
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| Authors: | SUN Jian-Bo JIANG Wei LI Ying ZHANG Yang-De and LI Ji-Lun |
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| Institution: | College of Biological Sciences; China Agricultural University; Key laboratory of Agro-Microbial Resource and Application; Ministry of Agriculture; Beijing 100094;College of Biological Sciences; China Agricultural University; Key laboratory of Agro-Microbial Resource and Application; Ministry of Agriculture; Beijing 100094;College of Biological Sciences; China Agricultural University; Key laboratory of Agro-Microbial Resource and Application; Ministry of Agriculture; Beijing 100094;Xiangya Hospital of Central South University; National Key Laboratory of Nano-biological Technology; Ministry of Health; Changsha 410008;College of Biological Sciences; China Agricultural University; Key laboratory of Agro-Microbial Resource and Application; Ministry of Agriculture; Beijing 100094 |
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| Abstract: | Magnetotactic bacteria can form uniform nanometer sized magnetic particles(megnetosomes)within the bacterial cells and each particle is enveloped in a membrane.The purified magnetosomes are compatible and less toxic to SD rat.It may be used as a carrier to link with certain antibiotics and larger molecular compounds for treatment of tumors.Here we described the properties of the magnetosnmes and the strategies for linking drugs.We also discussed the possibility to establish the system of targeted therapy for cancers nsing drug-loaded magnetosumes. |
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| Keywords: | Magnetotactic bacteria Magnetosome Nano-carrier |
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