| 过氧化物酶体与病原真菌的致病性 |
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| 引用本文： | 李荔,张克勤,杨金奎.过氧化物酶体与病原真菌的致病性[J].微生物学通报,2011,38(6):934-941. |
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| 作者姓名： | 李荔 张克勤 杨金奎 |
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| 作者单位： | 云南大学 生物资源保护与利用国家重点实验室培育基地和西南微生物多样性教育部重点实验室,云南昆明,650091 |
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| 基金项目： | 国家自然科学基金项目(No. 30960229); 中国科学院西部之光人才培养计划项目(杨金奎); 云南省中青年学术和技术带头人后备人才项目(No. 2009CI052) |
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| 摘 要： | 过氧化物酶体(Peroxisome)是一类单层膜的细胞器,普遍存在于各种真核细胞中。过氧化物酶体是丰富的酶库,含有至少50种酶类,参与生物体的多种生理代谢过程,如乙醛酸循环、脂肪酸的β-氧化及活性氧的调节等。近年来,日益增多的研究表明过氧化物酶体和病原真菌的乙醛酸循环及脂肪酸的β-氧化功能的发挥密切相关,并影响病原真菌的致病性。总结过氧化物酶体中酶的种类和功能,评述过氧化物酶体与乙醛酸循环、脂肪酸β-氧化和病原真菌致病性的关系。
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| 关 键 词： | 病原真菌 过氧化物酶体 乙醛酸循环 脂肪酸β-氧化 致病性 |
Peroxisome and pathogenicity of pathogenic fungi |
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| LI Li,ZHANG Ke-Qin and YANG Jin-Kui.Peroxisome and pathogenicity of pathogenic fungi[J].Microbiology,2011,38(6):934-941. |
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| Authors: | LI Li ZHANG Ke-Qin and YANG Jin-Kui |
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| Institution: | Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan University, Kunming, Yunnan 650091, China |
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| Abstract: | Peroxisome,an organelle with a single membrane,lies in various eukaryotic cells.Perox-isome contains more than 50 enzymes,involved in multiple physiological metabolic processes in or-ganisms,such as the glyoxylate cycle,β-oxidation of fatty acid and regulation of active oxygen.Re-cently,increasing studies showed peroxisome influence on the glyoxylate cycle,β-oxidation of fatty acid,and pathogenicities of pathogenic fungi.In this review,types and functions of enzymes in perox-isome,metabolic processes related to peroxisome and relationship between peroxisome and patho-genicities of pathogenic fungi were summaried. |
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| Keywords: | Pathogenic fungi Peroxisome Glyoxylate cycle β-Oxidation of fatty acid Pathogenicity |
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