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Common molecular pathways involved in human CD133+/CD34+ progenitor cell expansion and cancer |
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| Authors: | Oswaldo Keith Okamoto Ana Carolina SR Carvalho Luciana C Marti Ricardo Z Vêncio Carlos A Moreira-Filho |
| Institution: | 1.Departamento de Neurologia e Neurocirurgia,Universidade Federal de S?o Paulo – Escola Paulista de Medicina,S?o Paulo,Brazil;2.Instituto Israelita de Ensino e Pesquisa Albert Einstein,S?o Paulo,Brazil;3.Institute for Systems Biology,Seattle,USA;4.Departamento de Imunologia,Instituto de Ciências Biomédicas, Universidade de S?o Paulo,S?o Paulo,Brazil |
| Abstract: | BackgroundUncovering the molecular mechanism underlying expansion of hematopoietic stem and progenitor cells is critical to extend current therapeutic applications and to understand how its deregulation relates to leukemia. The characterization of genes commonly relevant to stem/progenitor cell expansion and tumor development should facilitate the identification of novel therapeutic targets in cancer. |
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