Effects of acupuncture on declined cerebral blood flow,impaired mitochondrial respiratory function and oxidative stress in multi-infarct dementia rats |
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| Institution: | 2. Department of Neurology, G. Genimatas General Hospital, Athens, Greece;3. Acute Stroke Unit, Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, Greece;4. Department of Neurology, Eginition Hospital, University of Athens Medical School, Athens, Greece;6. Stroke Division, Hellenic Cardiovascular Research Society, Athens, Greece;1. Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, 8200 Walnut Hill Ln, Dallas, TX 75231, USA;2. Department of Internal Medicine, University of Texas Southwestern Medical Center, 1801 Inwood Rd, Dallas, TX 75235, USA;3. Department of Geriatric Medicine, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, Netherlands;4. Department of Radiology and Psychology, Michigan State University, 220 Trowbridge Rd, East Lansing, MI 48824, USA;5. Cognitive Imaging Research Center, Michigan State University, 220 Trowbridge Rd, East Lansing, MI 48824, USA;6. Department of Psychiatry, University of Texas Southwestern Medical Center, 1801 Inwood Rd, Dallas, TX 75235, USA;7. Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 1801 Inwood Rd, Dallas, TX 75235, USA;8. Texas Alzheimer''s and Memory Disorders, Texas Health Presbyterian Hospital Dallas, 8200 Walnut Hill Ln, Dallas, TX 75231, USA;9. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 1801 Inwood Rd, Dallas, TX 75235, USA;1. Department of Neuroscience, Center for Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Republic of Korea;2. Department of Pharmacology, Center for Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Republic of Korea;3. Department of Biological Sciences, Center for Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Republic of Korea;4. Department of Neurology, Konkuk University Medical Center, 120-1 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Republic of Korea;5. Department of Neurology, College of Medicine, Hanyang University, 17 Heangdang-dong, Seongdong-gu, Seoul, Republic of Korea |
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| Abstract: | Brain energy disorders and oxidative stress due to chronic hypoperfusion were considered to be the major risk factors in the pathogenesis of dementia. In previous studies, we have demonstrated that acupuncture treatment improved cognitive function of VaD patients and multi-infarct dementia (MID) rats. Acupuncture therapy also increased the activities of glycometabolic enzymes in the brain. But it is not clear whether acupuncture treatment compensates neuronal energy deficit after cerebral ischemic through enhancing the activities of glucose metabolic enzymes and preserving mitochondrial function, and whether acupuncture neuroprotective effect is associated with activations of mitochondrial antioxidative defense system. So, the effect of acupuncture therapy on cognitive function, cerebral blood flow (CBF), mitochondrial respiratory function and oxidative stress in the brain of MID rats was investigated in this study. The results showed that acupuncture treatment significantly improved cognitive abilities and increased regional CBF of MID rats. Acupuncture elevated the activities of total SOD, CuZnSOD and MnSOD, decreased the level of malondialdehyde (MDA) and superoxide anion, regulated the ratio of reduced glutathione (GSH) and oxidized glutathione (GSSG) in mitochondria, and raised the level of the respiratory control index (RCI) and P/O ratio and the activities of mitochondrial respiratory enzymes of MID rats. These results indicated that acupuncture treatment improved cognitive function of MID rats; and this improvement might be due to increased CBF, which ameliorated mitochondrial dysfunction induced by ischemia and endogenous oxidative stress system of brain. |
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| Keywords: | Acupuncture Vascular dementia Cerebral blood flow Mitochondrial respiration Oxidative stress |
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