| 脐带血干细胞移植治疗非恶性血液病进展 |
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| 引用本文： | 王苹,翟晓文.脐带血干细胞移植治疗非恶性血液病进展[J].中华细胞与干细胞杂志(电子版),2019,9(4):242-246. |
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| 作者姓名： | 王苹 翟晓文 |
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| 作者单位： | 1. 201102 上海，复旦大学附属儿科医院血液科 |
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| 摘 要： | 异基因造血干细胞移植（allo-HSCT）是治愈多种非恶性病的有效方法。脐带血干细胞（UCB）具有免疫原性低、人类白细胞抗原不合耐受性好、移植物抗宿主反应发生率低以及获取相对快捷等特点，可作为非恶性血液疾病患者allo-HSCT的来源。本文简要综述脐血干细胞移植在原发性免疫缺陷病、遗传性骨髓衰竭、遗传代谢病以及自身免疫性疾病等非恶性血液疾病的治疗效果。
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| 关 键 词： | 脐带血 造血干细胞 移植 非恶性疾病 |
| 收稿时间： | 2019-06-21 |
Umbilical cord blood stem cell transplantation for non-malignant hematological diseases |
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| Authors: | Ping Wang Xiaowen Zhai |
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| Institution: | 1. Department of Hematology/oncology, Children's Hospital of Fudan University, Shanghai 201102, China |
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| Abstract: | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method to cure non-malignant hematological diseases. Umbilical cord blood stem cells (UCB) are characterized by weak immunogenicity, good tolerance human leukocyte antigen (HLA) mismatch, low incidence of graft-versus-host disease and relatively fast availability. UCB can be used as the graft of allo-HSCT for patients with non-malignant hematological diseases. This article reviews the efficacy of the umbilical cord blood stem cell transplantation (UCBT) in patients with primary immunodeficiency, hereditary bone marrow failure, hereditary metabolic diseases and autoimmune diseases. |
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| Keywords: | Umbilical cord blood Stem cells Transplantation Non-malignant diseases |
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