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亲属活体供肾的病理改变及其临床相关性
引用本文:陈正,潘光辉,方佳丽,廖德怀,李光辉,杜杨春,徐璐.亲属活体供肾的病理改变及其临床相关性[J].中华细胞与干细胞杂志(电子版),2011(1):53-56.
作者姓名:陈正  潘光辉  方佳丽  廖德怀  李光辉  杜杨春  徐璐
作者单位:广州医学院第二附属医院器官移植科,广州510260
摘    要:目的 探讨亲属活体供肾的病理改变与类型,分析供肾病理改变与供体临床预后的相关性.方法 2007 年5 月至2008 年7 月完成59 例亲属活体供肾肾移植,供肾灌注后用Trucut 肾活检针(18 G)行肾下极穿刺活检,常规行光镜检查和免疫组化检查.供体术后观察血清肌酐、尿常规和尿生化等.结果 55 岁以下供者肾脏出现...

关 键 词:亲属  活体供者  肾移植  肾活检

Renal biopsy findings of living-related donors and their correction with post-surgery recovery
Authors:CHEN Zheny  PAN Guang-hui  FANG Jia-li  LIAO De-huai  LI Guang-hui  DU Yang- chun  XU Lu
Institution:. (The 2nd Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, China)
Abstract:Objective To evaluate the potential pathological changes of living-related donor kidney and the correlation between pathological changes and post-surgery recovery. Methods From May 2007 to July 2008 kidney biopsy were performed in 59 living-related donors during surgeries. None of the donors had abnormal findings at preoperative examinations. RelatiOnship between the kidney biopsy findings and recovery of donors was analyzed. Results Fifty-nine renal biopsies were performed during operations, and pathological changes were found in 14 cases, including mesangial proliferative glomerulonephritis in 1 case, renal small artery intimal hyperplasia and hyaline degeneration in 1 case, glomerular basement membrane thickening or mesentery proliferative lesions in 6 cases and glomerulosclerosis in 6 cases respectively. For donors without pathological changes in their kidneys, the percentage of donors with high-than-normal serum creatinine level after operation was 28.9 %, and the creatinine level became normal after 1.22 ± 2.11 days. Also the incidence of proteinuria after operation was about 77.8 % and it lasted 3.67 ± 2.45 days. For donors with pathological changes in their kidneys, the percentage of donors with high-than-normal serum creatinine level after operation was about 50.0 % and he creatinine level became normal after 4.20 ± 6.71 days. The incidence of proteinuria was about 71.4 % and it lasted 4.20 ± 4.76 days. In 33 donors younger than 55 years, 7 were found to have pathological changes in kidney, while in 26 donors older than 55 years, 7 were found to have pathological changes in kidney. Conclusions There is no significant differences in the incidence of abnormal Scr level and proteinuria, and the duration of abnormal Scr level and proteinuria between donors with or without pathologic changes.
Keywords:Relatives  Living donor  Renal transplantation  Kidney biopsy
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