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人类白细胞抗原半相合供者外周血细胞因子诱导的杀伤细胞治疗晚期原发性肝癌二例
引用本文:叶扶光,许怡薇,姚尚志,张鑫,肖漓,马锡慧,高钰,冯凯,石炳毅.人类白细胞抗原半相合供者外周血细胞因子诱导的杀伤细胞治疗晚期原发性肝癌二例[J].中华细胞与干细胞杂志(电子版),2011(1):46-48.
作者姓名:叶扶光  许怡薇  姚尚志  张鑫  肖漓  马锡慧  高钰  冯凯  石炳毅
作者单位:中国人民解放军第三0九医院器官移植中心细胞治疗科,北京100091
摘    要:目的 观察半相合供者细胞因子诱导的杀伤细胞(CIK)治疗晚期肝癌的临床疗效。方法 两例无法手术且无法耐受化疗的晚期肝癌患者分别选取人类白细胞抗原(HLA)半相合健康供者体外培养CIK,14 d后分次回输给相应患者,观察患者治疗前后瘤体大小、肿瘤标志物、免疫指标、临床症状、生活质量和卡氏评分等的变化。结果 2例患者治疗后甲胎蛋白(AFP)分别下降9835 ng/L和7000 ng/L、临床症状较治疗前有明显改善。结论 初步结果显示,HLA半相合供者外周血CIK细胞治疗能改善晚期肝癌患者症状,并提高生活质量。

关 键 词:人类白细胞抗原  细胞因子诱导的杀伤细胞  晚期肝癌  免疫治疗

Treatment of advanced liver cancer by cytokine induced killer cells from haploidentical donor: a report of two cases
Authors:YE Fu-guang  XU Yi-wei  YAO Shang-zhi  ZHANG Xin  XIAO Li  MA Xi-hui  GAO Yu  FENG Kai  SHI Bing-yi
Institution:.( Departments of Cellular Therapy, PLA Organ Transplantation Centre, the No.309 Hospital of PLA, Beijing 100091, China)
Abstract:Objective To estimate the clinical effects of cytokine induced killer cells (CIK) from HLA haploidentical donor on patients with advanced liver cancer. Methods The donor's peripheral blood CIK cells were cultured in vitro, then transfused to two patients with advanced liver cancer. The tumor size, tumor markers, immune indexes, quality of life, and the Karnofsky's score were monitored before and after CIK cell transfusion. Results The AFP levels of the two patients were decreased by 9835 and 7000 ng/L respectively after treatment. The clinical symptoms of the two patients improved.. Conclusion CIK cells from HLA haploidentical donor can improve the clinical symptom and quality of life for patients with advanced liver cancer.
Keywords:Human leucocyte antigen  Cytokine induced killer cells  Advanced livercancer  Adoptive immunotherapy
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