Role of Imaging Tests for Preoperative Location of Pathologic Parathyroid Tissue in Patients with Primary Hyperparathyroidism |
| |
| Institution: | 1. From the Endocrine Unit, Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione (IEDE), Rio de Janeiro, Brazil;2. Department of Internal Medicine and Endocrine Unit, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil;3. Endocrine Unit Hospital Universitário Pedro Ernesto, Rio de Janeiro, Brazil;4. Endocrine Unit, Hospital Federal da Lagoa, Rio de Janeiro, Brazil.;1. Retrovirus Center, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy;2. ARPA Foundation, Pisa, Italy;3. North-Western Tuscany Blood Bank, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy;4. Transfusion Medicine and Transplant Biology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy;5. Center for Spinal Cord Injuries, Department of Neurosciences, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy;6. Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy;1. Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China;2. Heart of England National Health Service Foundation Trust, Bordesley Green, East Birmingham, UK;3. Guy''s and St Thomas'' Hospital National Health Service Foundation Trust, London, UK;4. Beijing Armed Police General Hospital, Beijing, China;5. Second Hospital of Lanzhou University, Lanzhou, China;6. Jing-Meng Stem Cell Company, Beijing, China;1. Veterinary Clinical Sciences, School of Veterinary Medicine, University College Dublin, Dublin, Ireland;2. Department of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands;3. Department of Internal Medicine, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands;1. Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China;2. Department of Joint Surgery, Panyu Central Hospital, Guangzhou 511400, China;3. Department of Anesthesiology, Panyu Central Hospital, Guangzhou 511400, China |
| |
| Abstract: | Objective: Primary hyperparathyroidism (PHPT) can be cured by parathyroidectomy, and the preoperative location of enlarged pathologic parathyroid glands is determined by imaging studies, especially cervical ultrasonography and scintigraphy scanning. The aim of this retrospective study was to evaluate the use of preoperative cervical ultrasonography and/or parathyroid scintigraphy in locating pathologic parathyroid tissue in a group of patients with PHPT followed in the same endocrine center.Methods: We examined the records of 61 patients who had undergone parathyroidectomy for PHPT following 99mTc-sestamibi scintigraphy scan and/or cervical ultrasonography. Scintigraphic and ultrasonographic findings were compared to histopathologic results of the surgical specimens.Results: Ultrasonography detected enlarged parathyroid glands in 87% (48/55) of patients with PHPT and 99mTc-sestamibi scintigraphy in 79% (37/47) of the cases. Ultrasonography was able to correctly predict the surgical findings in 75% (41/55) of patients and scintigraphy in 72% (34/47). Of 7 patients who had negative ultrasonography, scintigraphy correctly predicted the surgical results in 2 (29%). Of 10 patients who had negative scintigraphy, ultrasonography correctly predicted the surgical results in 4 (40%). When we analyzed only patients with solitary eutopic parathyroid adenomas, the predictive positive values of ultrasonography and scintigraphy were 90% and 86%, respectively.Conclusion: Cervical ultrasonography had a higher likelihood of a correct positive test and a greater predictive positive value for solitary adenoma compared to 99mTc-sestamibi and should be used as the first diagnostic tool for preoperative localization of affected parathyroid glands in PHPT.Abbreviations:Ca = calciumIEDE = Instituto Estadual de Diabetes e Endocrinologia Luiz CapriglionePHPT = primary hyperparathyroidismPTH = parathyroid hormone |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
