The Stumble—From Pipe Cleaner to Bone Builder |
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| Institution: | 1. Medical Service, Department of Veterans Affairs Northern California Health Care System, Martinez, California.;2. Division of Endocrinology, Clinical Nutrition and Vascular Medicine, Department of Internal Medicine, University of California, Davis School of Medicine, Sacramento, California.;3. Division of Endocrinology, Diabetes and Nutrition, University of Maryland Medical Center, Baltimore, Maryland,;4. Division of Endocrinology, Washington Hospital Center, Washington, District of Columbia.;1. Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria;2. Department of Pharmaceutics, University of Nigeria, Nsukka, Enugu State, Nigeria |
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| Abstract: | ObjectiveTo review the history of the transition of bisphosphonate use from bench chemistry to clinical applications.MethodsPertinent medical literature, including limited-distribution as well as peer-reviewed publications, was reviewed.ResultsBisphosphonates were originally developed to interfere with calcium deposition. An expanded understanding of bone physiology, as well as a growing appreciation of bisphosphonate chemistry, allowed a broadening range of clinical applications.ConclusionThe use of bisphosphonates in clinical medicine depended on a series of fortuitous events that, at the time, were “stumbles,” not unlike the discoveries of Fleming and Newton. The logical sequence is more apparent in retrospect. (Endocr Pract. 2007;13:194-197) |
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