Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression |
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| Institution: | 1. Tissue Biomechanics Lab, Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA;2. Department of Mechanical and Aerospace Engineering, University of Miami, P.O. Box 248294, Coral Gables, FL, 33124-0624, USA;1. Department of Engineering Science, University of Oxford, Oxford, UK;2. Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust, Oxford, UK;1. Department of Information Engineering, Political Sciences and Communication Sciences, University of Sassari, Viale Mancini, 5, 07100 Sassari, Italy;2. Orthopaedic Department, University Hospital Basel, University of Basel, Basel, Switzerland;1. Department of Mechanical Engineering, University of British Columbia, Vancouver, Canada;2. Department of Orthopeadics, University of British Columbia, Vancouver, Canada;3. Centre for Hip Health and Mobility, Vancouver, Canada;4. International Collaboration on Repair Discoveries, Vancouver, Canada;5. McCaig Institute for Bone and Joint Health University of Calgary, Calgary, Canada;6. Department of Medicine, Columbia University, New York, USA;7. Department of Geriatric Medicine, University of British Columbia, Vancouver, Canada;1. Department of Biomedical Engineering, University of California, One Shields Avenue, Davis, CA 95616, USA;2. Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA;3. Department of Orthopaedic Surgery, University of California, One Shields Avenue, Davis, CA 95616, USA;1. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA;2. Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA;3. Hospital for Special Surgery, New York, NY, USA;4. Departments of Mechanical Engineering and Bioengineering, University of California, Berkeley, CA, USA |
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| Abstract: | In this study, a three-dimensional finite element model was used to investigate the changes in tissue composition and mechanical signals within human lumbar intervertebral disc during the degenerative progression. This model was developed based on the cell-activity coupled mechano-electrochemical mixture theory. The disc degeneration was simulated by lowering nutrition levels at disc boundaries, and the temporal and spatial distributions of the fixed charge density, water content, fluid pressure, Von Mises stress, and disc deformation were analyzed. Results showed that fixed charge density, fluid pressure, and water content decreased significantly in the nucleus pulposus (NP) and the inner to middle annulus fibrosus (AF) regions of the degenerative disc. It was found that, with degenerative progression, the Von Mises stress (relative to that at healthy state) increased within the disc, with a larger increase in the outer AF region. Both the disc volume and height decreased with the degenerative progression. The predicted results of fluid pressure change in the NP were consistent with experimental findings in the literature. The knowledge of the variations of temporal and spatial distributions of composition and mechanical signals within the human IVDs provide a better understanding of the progression of disc degeneration. |
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| Keywords: | Biomechanics Mechanobiology Intervertebral disc degeneration Continuum mixture theory Finite element method Modeling Biophysics |
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