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Apoptosis induced by granzyme B |
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| Authors: | A V Sintsov E I Kovalenko M A Khanin |
| Institution: | (1) Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991, Russia;(2) Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya, 16/10, Moscow, 117997, Russia |
| Abstract: | Results of biochemical studies of apoptosis reactions induced by granzyme B are considered and summarized. Special attention is paid to the reactions of procaspase activation and limited proteolysis of apoptotic targets. Found values of kinetic constants of granzyme B-mediated enzymatic reactions are listed. |
| Keywords: | apoptosis caspase activation granzyme B perforin proteolytic kinetic constants |
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