DNA mimics based on pyrrolidine and hydroxyproline |
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Authors: | V A Efimov A V Aralov O G Chakhmakhcheva |
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Institution: | 1.Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry,Russian Academy of Sciences,Moscow,Russia |
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Abstract: | In recent years, a great number of analogues and mimics of nucleic acids have been developed with the aim of improving the
physicochemical and biological properties of native oligonucleotides, in particular, to increase their affinity for nucleic
acids, selectivity of action, and biological stability. This review summarizes the data on the synthesis and properties of
DNA mimics, the analogues of peptide nucleic acids, which are the derivatives of pyrrolidine and hydroxyproline. Some physicochemical
and biological properties of negatively charged mimics of this type are considered, which contain phosphonate residues in
the back-bone and exhibit a high affinity for DNA and RNA, the selectivity of binding to nucleic acids, and stability in various
biological systems. Examples of using these mimics as tools in molecular biology studies, in particular, functional genomics,
are given. The prospects for their application in diagnosis and medicine are discussed. |
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