The hidden potential of glycomarkers: Glycosylation studies in the service of cancer diagnosis and treatment期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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The hidden potential of glycomarkers: Glycosylation studies in the service of cancer diagnosis and treatment

Institution:	1. Jagiellonian University, Faculty of Biology, Institute of Zoology and Biomedical Research, Department of Glycoconjugate Biochemistry, Gronostajowa 9 Street, 30-387 Cracow, Poland;2. Doctoral School of Exact and Natural Sciences, Faculty of Biology, Jagiellonian University, Prof. S. ?ojasiewicza 11 Street, 30-348 Cracow, Poland

Abstract:	Changes in the glycosylation process appear early in carcinogenesis and evolve with the growth and spread of cancer. The correlation of the characteristic glycosylation signature with the tumor stage and the appropriate therapy choice is an important issue in translational medicine. Oncologists also pay attention to extracellular vesicles as reservoirs of new cancer glycomarkers that can be potent for cancer diagnosis/prognosis. In this review, we recall glycomarkers used in oncology and show their new glycoforms of improved clinical relevance. We summarize current knowledge on the biological functions of glycoepitopes in cancer-derived extracellular vesicles and their potential use in clinical practice. Is glycomics a future of cancer diagnosis? It may be, but in combination with other omics analyses than alone.

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