Targeting cellular apoptotic pathway with peptides from marine organisms |
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Authors: | Lanhong Zheng Xiukun Lin Ning Wu Ming Liu Yuan Zheng Jun Sheng Xiaofeng Ji Mi Sun |
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Affiliation: | 1. Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China;2. Department of Pharmacology, Capital Medical University, Beijing, China;3. Institute of Oceanology, Chinese Academy of Science, Qingdao, China |
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Abstract: | Apoptosis is a critical defense mechanism against the formation and progression of cancer and exhibits distinct morphological and biochemical traits. Targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents. Peptides from marine organisms have become important sources in the discovery of antitumor drugs, especially when modern technology makes it more and more feasible to collect organisms from seas. This primer summarizes several marine peptides, based on their effects on apoptotic signaling pathways, although most of these peptides have not yet been studied in depth for their mechanisms of action. Novel peptides that induce an apoptosis signal pathway are presented in association with their pharmacological properties. |
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Keywords: | JNK, Jun N-terminal kinase MAPK, mitogen-activated protein kinase PI3K, phosphatidylinositol 3 kinase AKT, serine/threonine-specific protein kinase Cty C, cytochrome c MMAE, monomethyl auristatin E SGN-35, brentuximab vedotin, Adcetris FDA, Food and Drug Administration HL, Hodgkin's lymphoma ALCL, anaplastic large cell lymphoma ROS, reactive oxygen species ScA, somocystinamide A C-PC, C-phycocyanin Apaf, apoptotic protease activating factors CS5931, polypeptide from Ciona savignyi Mere15, polypeptide from Meretrix meretrix PARP, poly ADP-ribose polymerase Aplidine, DDB, dehydrodidemnin B PKC-d, protein kinase C delta EGFR, epidermal growth factor receptor KF, Kahalalide F PM02734, elisidepsin trifluoroacetate, Irvalec NFkappa B, nuclear factor kappa B TNF, tumor necrosis factor |
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