首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Neuropeptides in coelenterates: a review
Authors:Grimmelikhuijzen  C J P  Graff  D  Koizumi  O  Westfall  J A  McFarlane  I D
Institution:(1) Centre for Molecular Neurobiology, University of Hamburg, Martinistr. 52, 2000 Hamburg 20, Germany;(2) Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, 66506 Manhattan, KS, USA;(3) Department of Applied Biology, University of Hull, HU6 7RX Hull, UK
Abstract:Coelenterate neurones produce peptides containing an Arg-Phe-NH2(RF-amide)-like carboxyterminus. RF-amide-like peptides are located in neuronal dense-cored vesicles, indicating that they are released by exocytosis and that they might function as neurotransmitters or neurohormones. Using a radioimmunoassay for the sequence RF-amide, 3 peptides were isolated from the sea anemone Anthopleura elegantissima: < Glu-Gly-Arg-Phe-NH2(Antho-RF-amide), 2(Antho-RWamide I) and 2(Antho-RW-amide II). The general structure of these peptides can be described as 2, where X is an aromatic amino acid. From the hydromedusa Polyorchis penicillatus, the peptide 2(Pol-RF-amide I) was isolated, which also belongs to the 2 family. Using specific antisera, it was shown that all 4 peptides were located in neurones, many of which were associated with smooth muscle fibres. Application of low doses of Antho-RF-amide or of Antho-RW-amide I and II induced contractions of endodermal muscles of sea anemones. This suggests that these peptides are transmitters or modulators at neuromuscular junctions.
Keywords:Neuropeptides  neurones  coelenterates
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号