A sticky situation: CCN1 promotes both proliferation and apoptosis of cancer cells |
| |
| Authors: | Andrew Leask |
| |
| Institution: | (1) CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Dental Sciences Building, University of Western Ontario, London, ON, N6A 5C1, Canada |
| |
| Abstract: | Connective tissue growth factor (CTGF/CCN2) is overexpressed in diabetes. Diabetic rats possess myocardial and cardiomyocyte
hypertrophy. In a recent report, Wang and colleagues (Am J Physiol Cell Physiol. 2009 Jul 22. Epub ahead of print]) show
that CCN2 directly mediates cardiomyocyte hypertrophy as well as that induced by high glucose and fatty acid. CCN2 acted via
the TrkA receptor. These data are the subject of this commentary, and emphasize that CCN2 may be an excellent target for therapy
in diabetes. |
| |
| Keywords: | cyr 61 CTGF CCN proteins CCN1 Cancer Prostate Matricellular proteins Adhesion |
| 本文献已被 SpringerLink 等数据库收录！ |
|
