Nanoelectropulse-driven membrane perturbation and small molecule permeabilization |
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| Authors: | P Thomas Vernier Yinghua Sun Martin A Gundersen |
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| Institution: | (1) Department of Electrical Engineering-Electrophysics, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089-0271, USA;(2) MOSIS, Information Sciences Institute, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90292-6695, USA;(3) Department of Materials Science and Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089-0271, USA |
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| Abstract: | Background Nanosecond, megavolt-per-meter pulsed electric fields scramble membrane phospholipids, release intracellular calcium, and
induce apoptosis. Flow cytometric and fluorescence microscopy evidence has associated phospholipid rearrangement directly
with nanoelectropulse exposure and supports the hypothesis that the potential that develops across the lipid bilayer during
an electric pulse drives phosphatidylserine (PS) externalization. |
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