Effect of soybean oil on atherogenic metabolic risks associated with estrogen deficiency in ovariectomized rats |
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Authors: | Hanaa A Hassan Mosaad A Abdel-Wahhab |
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Institution: | (1) Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt;(2) Food Toxicology and Contaminants Department, National Research Center, Dokki, Cairo, Egypt |
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Abstract: | The aim of the present study was to investigate the cardiac biomarker changes in experimental bilateral ovariectomized (OVX)
rats in addition to evaluating the role of soybean oil-supplemented diet to attenuate these alterations. Female rats were
divided into four groups and treated for 2 months as follows: groups 1 and 2 fed with standard diet with or without 15% soybean
oil. Groups 3 and 4 were bilateral OVX and received the standard diet with or without 15% soybean oil. The results revealed
that rats subjected to ovariectomy exhibited an inhibition in estrogen and high-density lipoprotein cholesterol levels and
marked increase of lipid profile, low-density lipoprotein cholesterol, and VLDL-C accompanied with a marked elevation in atherogenic
index, cardiac enzyme activity, tumor necrosis factor-α, and C-reactive protein. Signs of cardiovascular injury which included
an increase in cardiac thiobarbituric acid-reactive substances were concomitantly noticed with a reduction in the reduced
glutathione, total antioxidant capacity, and superoxide dismutase. However, supplementation of soybean oil resulted in the
restoration of the changed lipid profile and improved cardiac biomarkers near to normal values as well as improved inflammatory
and antioxidant status. It was concluded that consumption of soybean oil may have a role in retarding atherosclerosis and
risk of cardiovascular disorders associated with estrogen deficiency in ovariectomy status. |
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