The distinct effects of a butanol fraction of <Emphasis Type="Italic">Bidens pilosa</Emphasis> plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice |
| |
| Authors: | Cicero?Lee-Tian?Chang Hui-Kai?Kuo Shu-Lin?Chang Yi-Ming?Chiang Tsung-Han?Lee Wen-Mein?Wu Lie-Fen?Shyur Email author" target="_blank">Wen-Chin?YangEmail author |
| |
| Institution: | (1) Institute of BioAgricultural Sciences, Academia Sinica, Taiwan, ROC;(2) Department of Life Sciences, National Chung Hsing University, Taiwan, ROC;(3) Department of Biological Science and Technology, National Chiao Tung University, ROC;(4) Department of Nutrition and Food Sciences, Fu Jen Catholic University, ROC |
| |
| Abstract: | Bidens pilosa is claimed to be useful for immune or anti-inflammatory disorders; however, little scientific evidence has been published concerning its function. In this paper, immune disease mouse models were used to study the function of a butanol fraction of B.pilosa. We demonstrated treatment with the butanol fraction of B.pilosa ameliorated Th1 cell-mediated autoimmune diabetes in nonobese diabetic (NOD) mice but caused deterioration of Th2 cell-mediated airway inflammation induced by ovalbumin (OVA) in BALB/c mice. We next showed that Th2 cytokines (IL-4 and/or IL-5) increased but Th1 cytokine (IFN- ) decreased following injections with the butanol fraction of B.pilosa in both mouse strains. Accordingly, Th2 cytokine-regulated IgE production in mouse serum increased following treatment with this fraction. Finally, we found that the butanol fraction of B.pilosa inhibited Th1 cell differentiation but promoted Th2 cell differentiation. Taken together, the butanol fraction of B.pilosa has a dichotomous effect on helper T cell-mediated immune disorders, plausibly via modulation of T cell differentiation. |
| |
| Keywords: | airway inflammation Bidens diabetes helper T cells (Th) |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
