A natural compound induced cardiogenic differentiation of endogenous MSCs for repair of infarcted heart |
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Authors: | Lin Xiaoli Peng Peng Cheng Lei Chen Shihui Li Karen Li Zhong Yu Mo Ye Hua Zhou Zhen Li Ming |
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Institution: | a Laboratory of Innovative Medicine, Hong Kong b Laboratory of Regenerative Medicine, Jinan University, Guangzhou, China c Medical School, University of Massachusetts, Worcester, US d Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong e Department of Pediatrics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong |
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Abstract: | An intra-myocardial injection of a cardiogenic factor (cardiogenin) was reported to induce myocardial regeneration of exogenous mesenchymal stem cell (MSCs) origin. In this study, replacement of the dangerous intra-myocardial injection with a safe method and whether the endogenous MSCs contribute to the cardiogenin-mediated myocardial regeneration were investigated. Bone marrow transplantation with labeled MSCs was performed in rats, which were subsequently subject to a permanent ligation of left anterior descending coronary artery one week after the transplantation. The rats were then treated with the cardiogenin through oral administration for 2 weeks. We not only demonstrated the substantial therapeutic effects of cardiogenin on myocardial infarction through an oral administration, but also provided direct evidences that the bone marrow derived endogenous MSCs are the major cellular source of the regenerating myocardium. Preliminary mechanistic studies suggested that miR-9 and its target E-cadherin may be required for intercalated disc formation. |
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Keywords: | Myocardial infarction Mesenchymal stem cells Cardiogenic differentiation Myocardial regeneration Cardiac myocytes |
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