Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses |
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Authors: | Juliana Perez Di Giorgio Gabriela Soto Karina Alleva Cintia Jozefkowicz Gabriela Amodeo Jorge Prometeo Muschietti Nicolás Daniel Ayub |
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Institution: | 1. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Hector Torres (INGEBI-CONICET), Vuelta de Obligado 2490, C1428ADN, Buenos Aires, Argentina 5. Instituto de Genética Ewald A. Favret (CICVyA-INTA), De los reseros S/N, Castelar, CC25 (1712), Buenos Aires, Argentina 2. Instituto de Biodiversidad y Biología Experimental y Aplicada (IBBEA, CONICET-UBA), Intendente Güiraldes 2160, Ciudad Universitaria, Pabellón II, C1428EGA, Buenos Aires, Argentina 3. Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, Ciudad Universitaria, Pabellón II, C1428EGA, Buenos Aires, Argentina 4. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Avda. Rivadavia 1917, C1033AAJ, Buenos Aires, Argentina
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Abstract: | Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that the assignment of orthologous AQPs is not possible, making it difficult to integrate functional information. Recently, a novel phylogenetic framework of eukaryotic AQP evolution showed congruence between eukaryotic AQPs and organismal trees identifying 32 orthologous clusters in plants and animals (Soto et al. Gene 503:165–176, 2012). In this article, we discuss in depth the methodological strength, the ability to predict functionality and the AQP community perception about the different paradigms of AQP evolution. Moreover, we show an updated review of AQPs transport functions in association with phylogenetic analyses. Finally, we discuss the possible effect of AQP data integration in the understanding of water and solute transport in eukaryotic cells. |
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