Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs |
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| Authors: | Gabriella Goldberg Daria Mochly-Rosen Sara Fuchs Yoram Lass |
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| Institution: | (1) Department of Physiology & Pharmacology, Sackler School of Medicine, Tel-Aviv University, 69978 Ramat-Aviv, Israel;(2) Department of Chemical Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel |
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| Abstract: | Summary Monoclonal antibodies directed against the cholinergic binding site of the acetylcholine receptor were found to alter the ion channel properties in cultured chick  myoballs. Time and dose dependent reduction in acetylcholine sensitivity was observed. Noise analysis experiments indicated a decrease in the mean single channel conductance and an increase in the mean single channel open time. |
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| Keywords: | acetylcholine receptor monoclonal antibody ionic channel ACh noise |
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