Initiation of Sodium Spikelets in Basal Dendrites of Neocortical Pyramidal Neurons |
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Authors: | BA?Milojkovic JP?Wuskell LM?Loew Email author" target="_blank">SD?AnticEmail author |
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Institution: | (1) Department of Neuroscience, Erasmus MC Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands;(2) Department of Cell Biology, UConn Health Center, 263 Farmington Ave., CT 06030, USA;(3) Department of Neuroscience, L-4000, UConn Health Center, 263 Farmington Ave., Farmington, CT 06030-3401, USA |
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Abstract: | Cortical information processing relies critically on the processing of electrical signals in pyramidal neurons. Electrical
transients mainly arise when excitatory synaptic inputs impinge upon distal dendritic regions. To study the dendritic aspect
of synaptic integration one must record electrical signals in distal dendrites. Since thin dendritic branches, such as oblique
and basal dendrites, do not support routine glass electrode measurements, we turned our effort towards voltage-sensitive dye
recordings. Using the optical imaging approach we found and reported previously that basal dendrites of neocortical pyramidal
neurons show an elaborate repertoire of electrical signals, including backpropagating action potentials and glutamate-evoked
plateau potentials. Here we report a novel form of electrical signal, qualitatively and quantitatively different from backpropagating
action potentials and dendritic plateau potentials. Strong glutamatergic stimulation of an individual basal dendrite is capable
of triggering a fast spike, which precedes the dendritic plateau potential. The amplitude of the fast initial spikelet was
actually smaller that the amplitude of the backpropagating action potential in the same dendritic segment. Therefore, the
fast initial spike was dubbed “spikelet”. Both the basal spikelet and plateau potential propagate decrementally towards the
cell body, where they are reflected in the somatic whole-cell recordings. The low incidence of basal spikelets in the somatic
intracellular recordings and the impact of basal spikelets on soma-axon action potential initiation are discussed. |
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Keywords: | Prefrontal cortex Pyramidal neurons Basal Dendrites Synaptic integration Dendritic Spikes Potentials UP states |
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