Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice |
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| Institution: | 1. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi?an Jiaotong University Health Science Center, 76 West Yanta Road, Xi?an 710061, Shaanxi, China;2. Cardiovascular Research Center, School of Basic Medical Sciences, Xi?an Jiaotong University Health Science Center, 76 West Yanta Road, Xi?an 710061, Shaanxi, China;3. Department of Physiology, Xi?an Medical University, 1 Xinwang Road, Xi?an 710021, Shaanxi, China;4. Xiamen Heart Center, Xiamen University, 201 South Hubin Road, Xiamen 361004, Fujian, China;1. Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, Sichuan, 610106, PR China;2. Department of Dermatology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400011, PR China;1. Servicios Científico-Técnicos Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Río Linares s/n, 33300-Villaviciosa, Asturias, Spain;2. Departamento de Microbiología y Bioquímica, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Río Linares s/n, 33300-Villaviciosa, Asturias, Spain;1. Nutrition-Diabetology department, CHU Bordeaux, avenue Magellan, 33600 Pessac, France;2. Rheumatology department, CHU Bordeaux, avenue Magellan, 33600 Pessac, France |
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| Abstract: | Rheumatoid arthritis (RA) is a chronic and systemic autoimmune inflammatory disease. Typical pathological findings of RA include persistent synovitis and bone degradation in the peripheral joints. Equol, a metabolite of the major soybean isoflavone daidzein, shows superior bioactivity than other isoflavones. We investigated the effects of equol administration on inflammatory response and bone erosion in mice with collagen-induced arthritis (CIA). The severity of arthritis symptoms was significantly low in the equol-administered CIA mice. In addition, equol administration improved the CIA-induced bone mineral density decline. In the inflamed area of CIA mice, equol administration suppressed the expression of interleukin-6 and its receptor. Furthermore, equol reduced the expression of genes associated with bone formation inhibition, osteoclast and immature osteoblast specificity and cartilage destruction. These results suggest that equol suppresses RA development and RA-induced bone erosion by regulating inflammation and bone metabolism. |
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