Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system |
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Authors: | Patrícia Gomes Cardoso Gilson Costa Macedo Vasco Azevedo Sergio Costa Oliveira |
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Institution: | (1) Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;(2) Department of General Biology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil |
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Abstract: | Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in professional and non-professional
phagocytes, and cause abortion in domestic animals and undulant fever in humans. Several species are recognized within the
genus Brucella and this classification is mainly based on the difference in pathogenicity and in host preference. Brucella strains may occur as either smooth or rough, expressing smooth LPS (S-LPS) or rough LPS (R-LPS) as major surface antigen.
This bacterium possesses an unconventional non-endotoxic lipopolysaccharide that confers resistance to anti-microbial attacks
and modulates the host immune response. The strains that are pathogenic for humans (B. abortus, B. suis, B. melitensis) carry a smooth LPS involved in the virulence of these bacteria. The LPS O-chain protects the bacteria from cellular cationic
peptides, oxygen metabolites and complement-mediated lysis and it is a key molecule for Brucella survival and replication in the host. Here, we review i) Brucella LPS structure; ii) Brucella genome, iii) genes involved in LPS biosynthesis; iv) the interaction between LPS and innate immunity. |
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