Engineered Trx2p industrial yeast strain protects glycolysis and fermentation proteins from oxidative carbonylation during biomass propagation |
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| Authors: | Rocío Gómez-Pastor Roberto Pérez-Torrado Elisa Cabiscol Joaquim Ros Emilia Matallana |
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| Institution: | 1.Departamento de Bioquímica y Biología Molecular,Universitat de València,Valencia,Spain;2.Departamento de Biotecnología,Instituto de Agroquímica y Tecnología de Alimentos, CSIC,Spain;3.Departament de Ciències Mèdiques Bàsiques,IRBLleida, Universitat de Lleida,Spain |
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| Abstract: | Background In the yeast biomass production process, protein carbonylation has severe adverse effects since it diminishes biomass yield
and profitability of industrial production plants. However, this significant detriment of yeast performance can be alleviated
by increasing thioredoxins levels. Thioredoxins are important antioxidant defenses implicated in many functions in cells,
and their primordial functions include scavenging of reactive oxygen species that produce dramatic and irreversible alterations
such as protein carbonylation. |
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