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Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis
Institution:1. David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;2. Department of Cell Biology, Radboud University Medical Centre, 6525 GA Nijmegen, the Netherlands;3. Department of Molecular Cancer Research, Center for Molecular Medicine, UMC Utrecht, the Netherlands;4. Oncode Institute, 3521 AL Utrecht, the Netherlands;5. Center for Theoretical Biological Physics, Department of Applied Physics, Rice University, Houston, TX 77005, USA;6. Department of Physics, Northeastern University, Boston, MA 02115, USA;7. Cancer Genomics Center, 3584 CG Utrecht, the Netherlands
Abstract:
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  • Keywords:Hypoxia  HIF  amoeboid migration  cancer cell  blebbing  calpain-2  integrin  cell metabolism  metastasis
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