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Prostaglandin-oxytocin Enhancement and Potentiation and their Clinical Applications
Authors:Arnold Gillespie
Abstract:The pharmacological phenomena of enhancement and potentiation of uterine response occur respectively when combinations of some prostaglandins and oxytocin are given serially and simultaneously to a patient. Employing these phenomena allows small doses of the drugs to achieve the same effects as a large dose given alone. In a pilot study of the use of the combination of prostaglandin and oxytocin for the induction of mid-trimester abortion seven of nine women were aborted within 48 hours. Side effects attributable to prostaglandin were eliminated or reduced in severity.
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