Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map |
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Authors: | Kazuhiro A Fujita Marek Ostaszewski Yukiko Matsuoka Samik Ghosh Enrico Glaab Christophe Trefois Isaac Crespo Thanneer M Perumal Wiktor Jurkowski Paul M A Antony Nico Diederich Manuel Buttini Akihiko Kodama Venkata P Satagopam Serge Eifes Antonio del Sol Reinhard Schneider Hiroaki Kitano Rudi Balling |
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Institution: | 1. The Systems Biology Institute, Minato-ku, Tokyo, Japan 2. Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7, Avenue des Hauts-Fourneaux, Esch-sur-Alzette, Luxembourg 3. Integrated Biobank of Luxembourg, Luxembourg City, Luxembourg 4. Department of Neuroscience, Centre Hospitalier Luxembourg, Luxembourg City, Luxembourg 5. Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan 6. Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany 7. Sony Computer Science Laboratories, Shinagawa-ku, Tokyo, Japan 8. Division of Systems Biology, Cancer Institute, Tokyo, Japan 9. Open Biology Unit, Okinawa Institute of Science and Technology, Kunigami, Okinawa, Japan
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Abstract: | Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused by a complex interplay of genetic and environmental factors. Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. Here we introduce a computationally tractable, comprehensive molecular interaction map of PD. This map integrates pathways implicated in PD pathogenesis such as synaptic and mitochondrial dysfunction, impaired protein degradation, alpha-synuclein pathobiology and neuroinflammation. We also present bioinformatics tools for the analysis, enrichment and annotation of the map, allowing the research community to open new avenues in PD research. The PD map is accessible at http://minerva.uni.lu/pd_map. |
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