Naturally occurring Mycobacterium scrofulaceum infection in a laboratory mouse colony. |
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| Authors: | K Ueda S Yamamoto Y Ohtsuka K Machii S Yamazaki H Saito |
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| Institution: | Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan. |
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| Abstract: | A contamination with Mycobacterium scrofulaceum was experienced in a colony of BALB/c-nu/nu mice. The contamination was noticed after introduction of C57BL/6 and C57BL/6. Lyt l. 1 strains into facilities that kept the colony. M. scrofulaceum seemed to be spread by oral infestation and cross-contamination of fecal excretions during handling of the mice. The organisms were shed continually or intermittently into feces of weaned nu/+ and nu/nu mice of BALB/c background, and were isolated from the mesenteric lymph nodes and spleen of some of the mice. Some of the bacillus-carrying mice developed serum antibody to M. scrofulaceum of IgG and IgA classes and gave a low degree of hypersensitivity to PPD from M. tuberculosis. |
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