Synthesis of Methylenecyclobutyl- and Cyclobutenyl Adenine,Potent Antiviral Carbocyclic Analogues of Oxetanocin A |
| |
Authors: | Tokumi Maruyama Yasuaki Hanai Yoshiko Sato |
| |
Institution: | Department of Pharmaceutical Sciences , Tokushima Bunri University , Yamashiro-cho, Tokushima, 770, JAPAN |
| |
Abstract: | Abstract 9-Cyclobutyladenines bearing both methylene and hydroxymethyl groups, 3 and 4, were prepared by dehydration of carbocyclic oxetanocin A (1a). Introduction of a double bond into cyclobutane ring was achieved by allylic oxidation of N 6-benzoyl-9-3-methylenecyclobutyl]adenine (12), which after several steps, afforded 9-3-(hydroxy-methyl)-2-cyclobutenyl)adenine (5). |
| |
Keywords: | |
|
|