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Synthesis and Biological Evaluation of Dideoxunucleosides Containing A Difluoromethylene Unit |
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| Authors: | Esa T Jarvi Prasad S Sunkara Terry L Bowlin |
| Institution: | Merrel Dow Research Institute , 2110 E. Galbraith Rd, Cincinnati, Ohio, 45215 |
| Abstract: | Abstract 2′-difluoro and 3′-difluoro dideoxynucleosides containing thymine and cytosine as the base were synthesized. These compounds inhibited HeLa cell growth and Moloney leukemia virus to a modest degree. |
| Keywords: | |