Mechanism of inactivation of S-adenosyl-L-homocysteine hydrolase by 5'-deoxy-5'-S-allenylthioadenosine and 5'-deoxy-5'-S-propynylthioadenosine |
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| Authors: | Guillerm G Guillerm D Witkowski-Vandenplas C |
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| Institution: | Laboratoire des Réactions Sélectives et Applications-UMR 6519, Université de Reims, BP 1039, 51687 Reims, France. |
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| Abstract: | 5'-Deoxy-5'-S-allenylthioadenosine 1 and 5'-deoxy-5'-S-propnylthioadenosine 2, derived from adenosine, were prepared. 1 and 2 caused irreversible inactivation of AdoHcy hydrolase. ESI mass spectra analysis of the inactivated enzyme demonstrated that 1 and 2 were type II "mechanism-based" inhibitors. |
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